Michael W. King
Executive Member, IU Center for Regenerative Biology and Medicine
Professor of Biochemistry and Molecular Biology, IU School Medicine
Professor of Biology, Indiana State University
Research Professor of Applied Biology and Biomedical Engineering, Rose-Hulman Institute of Technology
Ph.D. Biochemistry, University of California at Riverside, 1984
Research being conducted in my laboratory centers on the isolation and characterization of novel factors involved in tissue regeneration. Frogs represent a useful animal model with which to study molecular mechanisms that drive regeneration and, conversely, which repress gene activity that could lead to inhibition of the regenerative capacity in higher vertebrates. In these species limbs and spinal cords regenerate well during larval stages, but gradually lose this ability as the animal approaches metamorphosis. Adult frogs do not regenerate and the response of these structures to surgical transection is normally similar to that of higher vertebrates. This stage difference in regenerative ability can be used to advantage experimentally to discover, by differential gene screening, the molecules and molecular pathways that drive regeneration or inhibit regeneration within the same species. This project is being carried out with a consortium of researchers at Indiana University, Bloomington, IUPUI Indianapolis and Eli Lilly and Co., Indianapolis.
Selected Publications from Last Five Years
Mescher, AL. Neff, AW, and King, MW (2016) Inflammation and Immunity of Organ Regeneration. Development and Comparative Immunology ePub Feb 16, 2016
Mescher, AL. Neff, AW, and King, MW 2013 Changes in the Inflammatory Response to Injury and Its Resolution during the Loss of Regenerative Capacity in Developing Xenopus Limbs. PLoS One 8(11) e80477
King, MW, Neff, AW, and Mescher, AL. 2012 The developing Xenopus limb as a model for studies on the balance between inflammation and regeneration. The Anatomical Record 295:1552-1561
Neff, AW, King, MW and Mescher, AL 2011 Dedifferentiation and the role of SALL4in reprogramming and patterning during amphibian limb regeneration. Development Dynamics 240:979-989
Wilson, JM, Martinez-De Luna,RI, El Hodiri, HM, Smith, R, King, MW, Mescher, AL, Neff, AW and Belecky-Adams, TL. 2010 RNA helicase Ddx39 is expressed in the developing central nervous system, limb, otic vesicle, branchial arches and facial mesenchyme of Xenopus laevis Gene Expression Patterns 10(1):44-52
Rao, N, Jhamb, D, Milner, DJ, Li, B, Song, F, Wang, M, Voss, SR, Palakal, M, King, MW, Saranjami, B, Nye, HLD, Cameron, JA, and Stocum, DL 2009 Proteomic analysis of blastema formation in regenerating axolotl limbs. BMC Biology 7:83
King, MW, and Henry, JJ. 2009 Gene expression profiles of lens regeneration and development in Xenopus laevis. Developmental Dynamics 238:2340-2356
King, MW, Neff, AW and Mescher, AL 2009 Proteomics analysis of regenerating amphibian limbs: changes during the onset of regeneration. International Journal of Developmental Biology 53:955-969
Lange Q&A USMLE Step 1, 6th edition, 2008. McGraw-Hill, NY
Lange Q&A USMLE Step 1, 5th edition, 2005. McGraw-Hill, NY
Appleton & Lange's Review for the USMLE Step 1, 4th edition, 2002. McGraw-Hill, NY
Integrative Medical Biochemistry: Examination and Board Review, King, MW 2014. McGraw-Hill, NY, NY.
Biochemistry: Examination and Board Review, Balcavage, WX and King, MW 1995. Appleton and Lange, Stamford, CT.
Textbook Book Chapters
King, MW 2008 2008 Chapter 3: Biochemistry, and Practice Tests (Chapter 8 - 14) in: Lange Q&A USMLE Step I, 6th ed. McGraw-Hill, NY, NY.
King, MW 2007 Chapter 7, pp 177-207: Genetic Mechanisms in Cell and Molecular Biology for Engineers, ed. Waite and Waite, McGraw-Hill, NY, NY.
King, MW 2007 Chapter 9, pp 233-253: Cellular Development in Cell and Molecular Biology for Engineers, ed. Waite and Waite, McGraw-Hill, NY, NY.